Brain-Predicted Age Associates With Psychopathology Dimensions in Youths

This study aimed to investigate whether dimensional constructs of psychopathology relate variation in patterns brain development and determine these share common neurodevelopmental profiles. Psychiatric symptom ratings from 9312 youths (8–21 years old) the Philadelphia Neurodevelopmental Cohort were parsed into 7 independent dimensions clinical representing conduct, anxiety, obsessive-compulsive, attention, depression, bipolar, psychosis symptoms. Using a subset this cohort with structural magnetic resonance imaging (n = 1313), normative model morphology was established then applied predict age We investigated deviation brain-predicted true chronological age, called gap, explained individual each dimension. Individual gap significantly associated (t 3.16, p .0016), obsessive-compulsive symptoms 2.5, .01), general 4.08, < .0001). Greater severity along that appeared older than expected for typically developing same age. Psychopathology clustered 2 modules based on shared loci where putative accelerated neurodevelopment most prominent. Patterns morphological frontal cortices psychosis, conduct (module 1), whereas acceleration evident subcortex insula remaining 2). Our findings suggest increased particularly cortex subcortical nuclei, underpins youths. neural substrates, despite clinically